CHCE Capabilties

Today’s complex health care problems demand that decision makers find creative, pragmatic, unbiased solutions.The Center on Health Care Effectiveness (CHCE) is a resource for policymakers, the public, and other stakeholders, offering broad-based expertise to provide objective evidence to inform today’s most difficult health care decisions. We use the best scientific methods to address challenging, real-world issues faced by patients, providers, and innovators, creating information they can use to improve health care on the ground.

We can provide:

  • Policy analyses and research syntheses relevant to developing and using comparative effectiveness research
  • Comprehensive and innovative delivery system research on implementing evidence-based practice
  • Technical assistance to policymakers and other stakeholders looking to use evidence to promote effective care

As the role of comparative effectiveness research in health care continues to grow, CHCE can provide policy and research expertise relevant to comparative effectiveness research. We offer:

  • Systematic reviews of clinical or delivery system interventions
  • Studies of the effect of interventions on care and clinical outcomes, including identifying differential effects for vulnerable populations
  • Evaluations of comparative effectiveness of alternative delivery system approaches
  • Policy analysis relevant to the development of comparative effectiveness research


Policymakers continue to explore the best ways to integrate comparative effectiveness research into clinical practice. Strategies include encouraging provider incentives to reward evidence-based practice and engaging patients and biomedical and clinical innovators in the development and use of comparative effectiveness research. At CHCE, we conduct research and policy analysis relevant to these various strategies:

  • Consumer outreach/social marketing
  • Public report cards
  • Value-based insurance design
  • Informed consumer choice
  • Special populations’ needs
  • Provider feedback reports
  • Provider payment reform
  • Practice organization changes
  • Malpractice reform
  • Pricing decisions and benefit design

For more than four decades, Mathematica has developed the substantive expertise, methodological skill, and corporate infrastructure needed to place us in the forefront of policy analysis and research on comparative effectiveness research. Our collaborative, collegial tradition brings together the best minds from inside and outside of the organization. Our broad-based reach allows us to draw on the talents of more than 150 health services researchers whose knowledge spans methodologies and disciplines. In addition, we have access to extensive data resources. CHCE can also tap the talents of our research partner, the Center for Studying Health System Change.

We offer expertise in:

  • Experimental and nonexperimental evaluation design
  • Qualitative and quantitative methods
  • Development and analysis of large databases
  • Medicaid Analytic Extract (MAX) data files
  • Medicare claims data
  • Multi-payer and other linked databases relevant to comparative effectiveness research
  • Cost analysis
  • Clinician and patient attitudes and preferences
  • Payment policy and payer-provider interface
  • Survey data